Важливість і значення поліморфізму генів при прееклампсії
DOI:
https://doi.org/10.15574/10.15574/HW.2016.114.45Ключові слова:
прееклампсія, окиснювальний стрес, гени системи детоксикаціїАнотація
У статті приведений систематичний огляд даних про взаємозв’язок між поліморфізмами генів системи детоксикації та розвитком прееклампсії (ПЕ). Представлено основні гени системи детоксикації (GSTPI, GSTМI, GSTТI, GРХI, ЕРНХI, SOD-2, SOD-3, CYPIAL, MTHЕR, MTR) та їхні функції. Становить інтерес можливість розрахунку індивідуального ризику розвитку ПЕ на підставі даних про наявність сполучень різних поліморфізмів у генотипі жінки. Питання щодо ранньої діагностики ПЕ залишається дискутабельним і до кінця не вивченим. Необхідно проводити подальше поглиблене розширене дослідження даної проблеми.Посилання
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