Тромбофілії та акушерські ускладнення

Автор(и)

  • В.О. Заболотнов Житомирський медичний інститут, Україна
  • О.О. Хватова Житомирський медичний інститут, Україна
  • Я.П. Сегедіна Житомирський медичний інститут, Україна

DOI:

https://doi.org/10.15574/HW.2019.138.56

Ключові слова:

тромбофілії, антифосфоліпідний синдром, акушерські ускладнення, невиношування

Анотація

У даній статті розглянуто питання взаємозв’язку тромбофілій з акушерськими ускладненнями.

У жінок зі звичним невиношуванням не слід проводити скринінг на спадкову тромбофілію. При звичному невиношуванні жінки повинні пройти скринінг перед настанням вагітності або на ранніх термінах для виявлення антифосфоліпідних антитіл. Позитивні результати скринінгу є показанням для призначення низькомолекулярного гепарину (НМГ) і ацетилсаліцилової кислоти. Жінок з ЕКО недоцільно обстежувати на спадкову тромбофілію і проводити терапію НМГ. Не слід також проводити оцінювання вродженої тромбофілії у жінок з невиношуванням, з наявністю в анамнезі народження дитини із затримкою росту, прееклампсії і передчасного відшарування нормально розташованої плаценти.

Посилання

Practice Bulletin Inherited Thrombophilias in Pregnancy ACOG 122; 3. (2013, Sep). https://doi.org/10.1097/01.AOG.0000433981.36184.4e; PMid:23963422

Salwa Khan, Joseph D Dickerman Thromb J. (2006). Hereditary thrombophilia 4: 15. https://doi.org/10.1186/1477-9560-4-15; PMid:16968541 PMCid:PMC1592479

Ariel Many, MD and Gideon Koren, Can Fam Physician. (2005, Feb). 1051(2): 199–201.

Curr Opin Obstet Gynecol. (2007, Dec). 19(6):573-7.

Stirrat GM. Recurrent miscarriage. (1990). Lancet 336:673–5. https://doi.org/10.1016/0140-6736(90)92159-F

Wyatt PR, Owolabi T, Meier C, Huang T. (2005). Age-specific risk of fetal loss observed in a second trimester serum screening population. Am J Obstet Gynecol 192:240–6. https://doi.org/10.1016/j.ajog.2004.06.099; PMid:15672031

Nakaz MOZ Ukrainy vid 03.11.2008 r. No. 624 «Klinichnyi protokol z akusherskoi dopomohy «Nevynoshuvannia vahitnosti».

Ventskivskyi BM, Kaminskyi VV, Hryshchenko VI, Zhylka NIa, Senchuk AIa, Astakhov VM ta in. (2009). Metodychni vkazivky dlia vykladachiv vyshchykh medychnykh navchalnykh zakladiv. K, «Chaika-Vsesvit»:380.

The Investigation and Treatment of Couples with Recurrent Firsttrimester and Second-trimester Miscarriage Green-top Guideline 17. (2011, Apr).

Wilson WA, Gharavi AE, Koike T, Lockshin MD, Branch DW, Piette JC et al. (1999). International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: report of an international workshop. Arthritis Rheum 42:1309–11. https://doi.org/10.1002/1529-0131(199907)42:7<1309::AID-ANR1>3.0.CO;2-F

Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R et al. (2006). International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 4:295–306. https://doi.org/10.1111/j.1538-7836.2006.01753.x; PMid:16420554

Lyden TW, Vogt E, Ng AK, Johnson PM, Rote NS. (1992). Monoclonal antiphospholipid antibody reactivity against human placental trophoblast. J Reprod Immunol 22:1–14. https://doi.org/10.1016/0165-0378(92)90002-L

Di Simon N, De Carolis S, Lanzone A, Ronsisvalle E, Giannice R, Caruso A. (1995). In vitro effect of antiphospholipid antibody-containing sera on basal and gonadotrophin releasing hormone-dependent human chorionic gonadotrophin release by cultured trophoblast cells. Placenta 16:75–83. https://doi.org/10.1016/0143-4004(95)90083-7

Sthoeger ZM, Mozes E, Tartakovsky B. (1993). Anti-cardiolipin antibodies induce pregnancy failure by impairing embryonic implantation. Proc Natl Acad Sci USA 90:6464–7. https://doi.org/10.1073/pnas.90.14.6464; PMid:8341656 PMCid:PMC46952

Katsuragawa H, Kanzaki H, Inoue T, Hirano T, Mori T, Rote NS. (1997). Monoclonal antibody against phosphatidylserine inhibits in vitro human trophoblastic hormone production and invasion. Biol Reprod 56:50–8. https://doi.org/10.1095/biolreprod56.1.50; PMid:9002632

Bose P, Black S, Kadyrov M, Weissenborn U, Neulen J, Regan L et al. (2005). Heparin and aspirin attenuate placental apoptosis in vitro: implications for early pregnancy failure. Am J Obstet Gynecol 192:23–30. https://doi.org/10.1016/j.ajog.2004.09.029; PMid:15671997

Salmon JE, Girardi G, Holers VM. (2003). Activation of complement mediates antiphospholipid antibody-induced pregnancy loss. Lupus 12:535–8. https://doi.org/10.1191/0961203303lu397oa; PMid:12892394

De Wolf F, Carreras LO, Moerman P, Vermylen J, Van Assche A, Renaer M. (1982). Decidual vasculopathy and extensive placental infarction in a patient with repeated thromboembolic accidents, recurrent fetal loss, and a lupus anticoagulant. Am J Obstet Gynecol 142:829–34. https://doi.org/10.1016/S0002-9378(16)32527-3

Out HJ, Kooijman CD, Bruinse HW, Derksen RH. (1991). Histopathological findings in placentae from patients with intra-uterine fetal death and anti-phospholipid antibodies. Eur J Obstet Gynecol Reprod Biol 41:179–86. https://doi.org/10.1016/0028-2243(91)90021-C

Peaceman AM, Rehnberg KA. (1993). The effect of immunoglobulin G fractions from patients with lupus anticoagulant on placental prostacyclin and thromboxane production. Am J Obstet Gynecol 169:1403–6. https://doi.org/10.1016/0002-9378(93)90408-B

Miyakis et al. (2006). J.Thromb.Haemost. 4: 295-306. https://doi.org/10.1111/j.1538-7836.2006.01753.x; PMid:16420554

Rai RS, Regan L, Clifford K, Pickering W et al. (1995). Antiphospholipid antibodies and beta-2-glycoprotein-I in 500 women with recurrent miscarriage: results of a comprehensive screening approach. Hum Reprod 10:2001–5. https://doi.org/10.1093/oxfordjournals.humrep.a136224; PMid:8567830

Lockwood CJ, Romero R, Feinberg RF et al. (1989). The prevalence and biologic significance of lupus anticoagulant and anticardiolipin antibodies in a general obstetric population. Am J Obstet Gynecol 161:369–73. https://doi.org/10.1016/0002-9378(89)90522-X

Pattison NS, Chamley LW, McKay EJ et al. (1993). Antiphospholipid antibodies in pregnancy: prevalence and clinical association. Br J Obstet Gynaecol 100:909–13. https://doi.org/10.1111/j.1471-0528.1993.tb15105.x; PMid:8217972

Rai RS, Clifford K, Cohen H, Regan L. (1995). High prospective fetal loss rate in untreated pregnancies of women with recurrent miscarriage and antiphospholipid antibodies. Hum Reprod 10:3301–4. https://doi.org/10.1093/oxfordjournals.humrep.a135907; PMid:8822463

Five Things Physicians and Patients Should Question Released (2014, Feb 3). (Items 1–5). Released 2016, February 1 (Items 6–10).

Empson M, Lassere M, Craig J, Scott J. (2005). Prevention of recurrent miscarriage for women with antiphospholipid antibody or lupus anticoagulant. Cochrane Database Syst Rev (2):CD002859. https://doi.org/10.1002/14651858.CD002859.pub2; PMid:15846641

Guideline of the European Society of Human Reproduction and Embryology Recurrent Pregnancy Loss (2017, Nov).

de Braekeleer M, Dao TN. (1990). Cytogenetic studies in couples experiencing repeated pregnancy losses. Hum Reprod 5:519–28. https://doi.org/10.1093/oxfordjournals.humrep.a137135; PMid:2203803

Clifford K, Rai R, Watson H, Regan L. (1994). An informative protocol for the investigation of recurrent miscarriage: preliminary experience of 500 consecutive cases. Hum Reprod 9:1328–32. https://doi.org/10.1093/oxfordjournals.humrep.a138703; PMid:7962442

Carp H, Dolitzky M, Tur-Kaspa I, Inbal A. (2002). Hereditary thrombophilias are not associated with a decreased live birth rate in women with recurrent miscarriage. Fertil Steril 78:58–62. https://doi.org/10.1016/S0015-0282(02)03152-7

Reducing the Risk of Venous Thromboembolism during Pregnancy and the Puerperium RCOG Green-top Guideline 37a. (2015, Apr).

Leslie Skeith, Marc Carrier, Risto Kaaja et al. (2016). A meta-analysis of low-molecular-weight heparin to prevent pregnancy loss in women with inherited thrombophilia Blood 127:1650-1655. https://doi.org/10.1182/blood-2015-12-626739; PMid:26837697

Kaandorp SP, Goddijn M, van der Post JA et al. (2010). Aspirin plus heparin or aspirin alone in women with recurrent miscarriage. N Engl J Med. 362:1586-1596. https://doi.org/10.1056/NEJMoa1000641; PMid:20335572

Rodger MA, Hague WM, Kingdom J et al. (2014). Antepartum dalteparin versus no antepartum dalteparin for the prevention of pregnancy complications in pregnant women with thrombophilia (TIPPS): a multinational open-label randomised trial. Lancet. 384:1673–1683. https://doi.org/10.1016/S0140-6736(14)60793-5

Le Bouteiller P, Piccinni MP. (2008). Human NK cells in pregnant uterus: why there? Am J Reprod Immunol 59:401–6. https://doi.org/10.1111/j.1600-0897.2008.00597.x; PMid:18405310

Kaandorp SP, van Mens TE, Middeldorp S et al. (2014). Time to conception and time to live birth in women with unexplained recurrent miscarriage. Hum Reprod 29:1146. https://doi.org/10.1093/humrep/deu052; PMid:24682612

Steinvil A, Raz R, Berliner S et al. (2012). Association of common thrombophilias and antiphospholipid antibodies with success rate of in vitro fertilisation. Thromb Haemost 108:1192. https://doi.org/10.1160/TH12-06-0381; PMid:23052827

Xiaofanq Tan, Zhenbo Yu, Jun Sao et al. (2016, Aug). J Assist Reprod Genet. 33(8): 1093–1098. https://doi.org/10.1007/s10815-016-0726-0; PMid:27216921 PMCid:PMC4974224

##submission.downloads##

Опубліковано

2019-03-30

Номер

Розділ

Акушерство